Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Grapefruit juice com- ponents inhibit cytochrome P-4503A4, reducing the presys- temic metabolism of drugs such as Simvastatin, Lovastatin and Atorvastatin. Grapefruit contains a chemical that interferes with your bodys ability to break down or metabolize certain statin medications.Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice.Grapefruit can also help lower cholesterol but inhibits a substance in your small. Lipitor helps decrease an enzyme found in the liver that produces cholesterol in the body. The FDA-approved prescribing information for Lipitor does warn about a grapefruit juice interaction, but only when consuming very large amounts (1.2 liters of juice!): References Lipitor is in the drug class known as statins, which are used for lowering bad cholesterol that can be found in human blood. Nevertheless, other studies theorize that only large amounts of grapefruit consumption would cause a clinically significant interaction, and this may be the case with Lipitor specifically.

In terms of the actual juice, some studies have shown that less than one cup (~240 mL) of 100% grapefruit juice can cause an interaction. Several sources report eating as little as one grapefruit can cause issues. Drinking excessive amounts of grapefruit (approximately 1 L/day) increased drug concentrations 250. However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known. Per the Lipitor package insert, one study showed that drinking one glass of grapefruit juice (8 ounces) with atorvastatin resulted in an increased drug concentration of 37. It has been fairly well documented that grapefruit juice can interact with several drugs, including Lipitor ( atorvastatin), a 'statin' medication used to lower cholesterol. Studies offer conflicting data on just how much grapefruit it takes to produce a clinically significant interaction. Scientific studies have shown that a group of. This condition affects less than 0.1 of people taking statins. A search of Dr Google will confirm that indeed you should not eat grapefruit if you are taking statins. Grapefruit and grapefruit juice can inhibit CYP3A metabolizing enzymes, which are responsible for Lipitor (atorvastatin) metabolism. Consuming grapefruit or grapefruit juice when taking statins comes with a rare but serious risk of rhabdomyolysis. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260 if taken at the same time (about 90 if taken 12 hours.

Statins and grapefruit